Updated information on use of crushing slow release Nifedipine (Adalat) as an alternative to immediate release Nifedipine.

21 August 2020

In October 2019, the Australian suppliers of immediate release Nifedipine discontinued 10mg and 20mg tablets from the Australian market. There is still no access to immediate release Nifedipine tablets.

TGA have recommended that immediate release Nifedipine tablets should be sourced from overseas suppliers.

RANZCOG has previously published a news item stating that the SR 20mg tablet when halved and crushed is the equivalent to the immediate release 10mg tablet. 

However subsequent advice confirms that Nifedipine slow release/sustained release/extended release should not be halved and crushed as an alternative to Nifedipine immediate release due to unpredictable pharmacokinetics and reports of serious adverse effects when this has been done.

The previous RANZCOG news item has now been retracted and is updated here.



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